 Spectrum --
July 2007
 Introduction:
Cancer vaccines are the newest weapon in the battle against
cancer. Vaccines promise to boost the body’s natural abilities to halt the
progression of the disease. Although standard cancer treatments such as
surgery, chemotherapy, and radiation have improved the clinical outcomes of
many patients, these treatments have limitations and toxicities that can deter
their utility. Thus, there is substantial market opportunity for cancer
vaccines.
Get the Answers You Need to Shape Your Strategy:
 Cancer vaccination trains the patient’s own immune system to
specifically recognize and destroy tumor cells without harming normal cells. What
requirements must a cancer vaccine satisfy to achieve significant clinical response?
Which patients are ideal candidates for cancer vaccination? Are clinical trial
data masking the true efficacy potential of cancer vaccines?
Manufacturers of cancer vaccines have faced considerable
regulatory and production challenges, particularly developers of personalized
vaccines that require the use of the patient’s own tissues. What are some of
the difficulties faced by manufacturers of cancer vaccines? Which key
development questions need to be considered before a developer pursues a
particular vaccination strategy?
Because of their ability to boost the body’s immune response
to the vaccine, cancer vaccine adjuvants have become critical components of any
cancer vaccine product. Companies in this arena should try to investigate ways
to incorporate adjuvants into their research. What are the key adjuvants now
in development for cancer vaccines, and which agent is showing the greatest
promise?
Scope:
Tumor immunology: Overview of the role that the immune
system plays in the prevention of cancer development.
The cancer vaccine concept: The ability of cancer
vaccines to train the patient’s immune system to recognize and destroy tumor
cells without harming normal cells.
Cancer vaccine strategies: Description and examples of
cell-based, protein-based, and vector-based vaccines.
Improving cancer vaccine efficacy: The use of adjuvants
and their role in boosting cancer vaccine efficacy.
Future perspectives: Key challenges faced by developers
of cancer vaccines.
Related Spectrum Reports:
Outlook for Cancer Vaccine Development
Cancer Biomarkers: New Tools for Transforming Cancer
Management
Oncology Pipelines: Is the Future Targeted Therapy?
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