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Emerging Diagnostic Technologies for Use in Psychiatric Indications

Authors
Sandra T. Chow, M.Sc.
Spectrum -- May 2008

  Introduction:

The diagnosis of psychiatric diseases is an inexact science and a slow process for physicians. No laboratory tests are available to determine the exact disease--or treatment. New diagnostic technologies could offer earlier, more specific diagnosis of a psychiatric disease and even direct potential drug therapy. In this report, we discuss the treatment challenges that confront physicians and patients and review current and emerging diagnostic tests that are expected to change the way in which psychiatric diseases are diagnosed. This report also features three Expert Commentaries, two offering input from the diagnostic technology industry, and one highlighting Decision Resources’ primary research with physicians who discuss their views of biomarker-based diagnostic tests for psychiatry.

  Get the Answers You Need to Shape Your Strategy:

The diagnosis of mental illness is far from an exact science, with no laboratory tests to confirm a disorder or offer treatment strategies. What technologies are emerging that will expedite diagnosis and treatment of psychiatric disorders? How will these technologies affect R&D within the pharmaceutical industry?

EEG, molecular, genetic, and imaging diagnostics are all poised for use in the field of psychiatry. How will the technologies that exist to aid diagnosis expand into the field of mental health? What companies already have clinical trials under way and what diagnostic tools are they using? How will these studies target patient response to some of today’s most popular psychiatric drugs? What challenges do manufacturers face when developing these diagnostics?

Expert Commentaries: two company executives and one market analyst discuss the impact of novel diagnostics in the psychiatric arena. What are thought leaders saying about the potential for biomarkers in mental health diagnosis and treatment? How will a new EEG tool help psychiatrists target drug therapy in their patients? How can gene-expression profiles lead to differential diagnoses or offer insight into disease-specific subtyping?

  Scope:

Difficulties diagnosing mental illness: addressing similar symptomatology; multiple mental illnesses in one patient; challenges in determining optimal treatment; current medical practice for psychiatric indications.

Current and emerging diagnostic technologies for psychiatric indications: EEG (Aspect Medical Systems, CNS Response, Memory Pharmaceuticals/Roche); molecular diagnostics (Clinical Data, CombiMatrix, Curidium Medica, Roche/Affymetrix, Vanda Pharmaceuticals); diagnostic imaging (Alseres).

Psychiatric disorders: attention-deficit/hyperactivity disorder; autism spectrum disorder; bipolar disorder; major depression; schizophrenia; psychotic disorders.

Business considerations: review of partnerships and licensing activities; benefits of drug/theranostic codevelopment; challenges and opportunities.

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Companies:

Affymetrix

Agilent Technologies

Alseres

Applera

Applied Biosystems

Aspect Medical Systems

Biogen Idec

Boston Life Sciences

Bristol-Myers Squibb

Cetus

Clinical Data

CNS Response

CombiMatrix

DNA Direct

Envivo Pharmaceuticals

Forest Laboratories

Genaissance Pharmaceuticals

Genelex

Genentech

GlaxoSmithKline

Illumina

Lundbeck

Memory Pharmaceuticals

Merck KGaA

Navigenics

Northstar Neuroscience

Novartis

Pfizer

PGxHealth

Roche

Vanda Pharmaceuticals

Zenyaku Kogyo




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