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Applications of Stem Cells in Drug Discovery

Authors
Lulu Pickering, Ph.D.
Spectrum -- January 2005

  In This Issue...

Stem cells are unspecialized cells that can differentiate into numerous types of specialized cells with specific functions. Diseases and disorders that might benefit from stem-cell research include Parkinson’s, Alzheimer’s, diabetes, cancer, heart disease, spinal cord injury, and multiple sclerosis, as well as organ transplantation and wound treatment. Stem cells are also a valuable source of material in drug discovery, high-content screening assays, and toxicology studies. In this report, we discuss the study of both undifferentiated stem cells and adult stem cells, the use of stem-cell biology to elucidate the pathways and mechanisms involved in different diseases, ongoing research to develop methods of using stem cells to replace disease-damaged cells, stem-cell-based drug discovery platforms, the use of stem cells in drug screening and toxicology, and the outlook for stem-cell-based drug discovery. We also profile companies and consortia involved in stem-cell research and examine the legal issues surrounding the field.

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